CCDC51

Across TCGA patient cohorts, CCDC51 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC51-associated genes across cancer lineages are 4E-BP1, eIF4E, and JNK_pT183_Y185. Each is linked with CCDC51 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC51-to-partner and partner-to-CCDC51 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CCDC51-low versus CCDC51-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC51→partner) and Y-score (partner→CCDC51) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.374	+3.199	.003	.009	3	2
UCEC	eIF4E →	+0.211	+3.000	.031	.036	2	2
UCEC	JNK_pT183_Y185 →	-0.185	-2.999	.018	.035	3	1
UCEC	JNK2 →	+0.331	+3.469	<.001	.002	3	1
UCEC	Ku80 →	+0.221	+3.009	.045	.019	3	1
UCEC	Notch1 →	+0.161	+2.584	.013	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

4E-BP1 by CCDC51 expression — UCEC

Explore this box plot interactively →