CCDC50

Across TCGA patient cohorts, CCDC50 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC50-associated genes across cancer lineages are Cyclin-B1, eEF2, and EGFR_pY1068. Each is linked with CCDC50 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC50-to-partner and partner-to-CCDC50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by CCDC50-low versus CCDC50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC50→partner) and Y-score (partner→CCDC50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.589	+3.169	.007	.018	3	3
UCEC	eEF2 →	+0.429	+2.321	.002	.033	3	2
UCEC	EGFR_pY1068 →	-0.283	-2.000	.004	.010	3	1
UCEC	ERK2 →	+0.224	+2.502	.003	.002	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.417	+1.584	.036	.036	3	1
UCEC	JNK2 →	+0.249	+2.331	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

Cyclin-B1 by CCDC50 expression — UCEC

Explore this box plot interactively →