CCDC42

Across TCGA patient cohorts, CCDC42 mutation is significantly associated with the RNA expression of many other genes, with 1,069 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC42-associated genes across cancer lineages are DGKZ, NMRAL1, and PDXK. Each is linked with CCDC42 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC42-to-partner and partner-to-CCDC42 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DGKZ grouped by CCDC42-low versus CCDC42-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC42→partner) and Y-score (partner→CCDC42) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DGKZ →	+0.329	+3.332	.008	.005	3	2
UCEC	NMRAL1 →	+0.373	+2.162	.004	.003	3	2
UCEC	PDXK →	+0.477	+3.499	.005	.002	3	2
UCEC	MON1A →	+0.414	+3.711	<.001	<.001	3	2
UCEC	TRUB2 →	+0.333	+3.871	.005	<.001	3	2
UCEC	ATP5MG →	+0.384	+2.732	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,069 associations by consensus.

DGKZ by CCDC42 expression — UCEC

Explore this box plot interactively →