CCDC34

Across TCGA pan-cancer cohorts, CCDC34 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CCDC34 data layer compared with 27 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher CCDC34 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC34 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

CESC, GBM, and SARC are the cancer types where CCDC34 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	OS	Median	II,III,IV	0.047	0.830	<.001	14	view →
GBM	DFS	Median	All	0.043	0.257	<.001	12	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
UCEC	DFS	Median	All	0.955	0.622	.035	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CCDC34–CESC (OS)

Open the CESC breakdown →