CCDC34

Across TCGA patient cohorts, CCDC34 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC34-associated genes across cancer lineages are EGFR_pY1068, A-Raf_pS299, and INPP4B. Each is linked with CCDC34 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC34-to-partner and partner-to-CCDC34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CCDC34-low versus CCDC34-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC34→partner) and Y-score (partner→CCDC34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.225	-2.906	.034	.001	3	1
UCEC	A-Raf_pS299 →	-0.140	-2.459	.005	.019	3	1
UCEC	INPP4B →	-0.346	-3.584	.011	.002	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-2.209	.003	.011	3	1
UCEC	Ku80 →	+0.348	+3.469	<.001	.002	3	1
UCEC	MEK1 →	+0.423	+2.700	.006	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

EGFR_pY1068 by CCDC34 expression — UCEC

Explore this box plot interactively →