CCDC34

Across TCGA cell cohorts, CCDC34 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CCDC34-associated genes across cancer lineages are LYZL1, SERPINA7, and ZAN. Each is linked with CCDC34 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC34-to-partner and partner-to-CCDC34 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYZL1 grouped by CCDC34-low versus CCDC34-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC34→partner) and Y-score (partner→CCDC34) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LYZL1 →	+0.031	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SERPINA7 →	+0.006	+5.228	.005	.005	3	1
LUNG_NSCLC_LUAD	ZAN →	+0.006	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	TARM1 →	+0.032	+5.662	<.001	.002	3	1
LARGE_INTESTINE	C6orf118 →	+0.186	+3.793	<.001	.007	3	1
BLOOD_Leukemia	ZIC5 →	+0.590	+3.474	<.001	.007	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

LYZL1 by CCDC34 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →