CCDC28B

Across TCGA pan-cancer cohorts, CCDC28B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated CCDC28B data layer compared with 3 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher CCDC28B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC28B expression acts as an unfavorable survival marker, although some lineages such as PAAD and LUAD show a favorable association.

KIRC, MESO, and PAAD are the cancer types where CCDC28B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.548	0.700	<.001	138	view →
MESO	OS	Median	II,III,IV	0.467	0.646	.001	50	view →
PAAD	OS	Tertile	All	0.513	0.214	<.001	42	view →
UCS	DFS	Median	IV	0.367	0.952	.001	38	view →
BLCA	DFS	Tertile	II,III,IV	0.256	0.490	.005	32	view →
LIHC	OS	Median	II,III,IV	0.452	0.750	<.001	31	view →
THYM	DFS	Quartile	II,III,IV	0.312	1.000	.001	27	view →
LUAD	OS	Tertile	II,III,IV	0.798	0.630	.002	20	view →
DLBC	DFS	Quartile	II,III,IV	1.000	0.118	.010	20	view →
BRCA	DFS	Quartile	All	0.690	0.344	<.001	19	view →
PRAD	DFS	Median	All	0.687	0.884	<.001	18	view →
UVM	OS	Quartile	III,IV	0.194	1.000	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

CCDC28B–KIRC (OS)

Open the KIRC breakdown →