CCDC28A

Across TCGA patient cohorts, CCDC28A mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC28A-associated genes across cancer lineages are PCNA, IGFBP2, and JNK_pT183_Y185. Each is linked with CCDC28A in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC28A-to-partner and partner-to-CCDC28A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by CCDC28A-low versus CCDC28A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC28A→partner) and Y-score (partner→CCDC28A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.251	+2.115	.007	.019	3	3
UCEC	IGFBP2 →	-0.811	-2.115	.004	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.204	-2.102	.005	.019	3	1
UCEC	JNK2 →	+0.278	+2.115	.001	.019	3	1
UCEC	Ku80 →	+0.223	+1.598	.030	.044	3	1
UCEC	MEK1 →	+0.513	+3.584	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

PCNA by CCDC28A expression — UCEC

Explore this box plot interactively →