CCDC27

Across TCGA pan-cancer cohorts, CCDC27 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated CCDC27 data layer compared with 17 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher CCDC27 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC27 expression acts as an unfavorable survival marker, although some lineages such as LUAD and SKCM show a favorable association.

OV, HNSC, and SARC are the cancer types where CCDC27 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	II,III,IV	0.007	0.844	<.001	48	view →
HNSC	OS	Median	II,III,IV	0.021	0.712	<.001	26	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
ACC	DFS	Median	All	0.195	0.748	.003	3	view →
LUAD	DFS	Median	All	1.000	0.335	.046	1	view →
SKCM	DFS	Median	II,III,IV	0.880	0.680	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

CCDC27–OV (OS)

Open the OV breakdown →