CCDC25

Across TCGA pan-cancer cohorts, CCDC25 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CCDC25 data layer compared with 21 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CCDC25 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC25 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and GBM are the cancer types where CCDC25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	1.000	0.441	.002	28	view →
PDAC	DFS	Quartile	All	0.590	0.329	.003	24	view →
GBM	DFS	Median	All	0.586	0.830	<.001	15	view →
HNSC	OS	Quartile	All	0.197	1.000	.017	14	view →
CCRCC	OS	Tertile	II,III,IV	1.000	0.796	.024	8	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CCDC25–UCEC (DFS)

Open the UCEC breakdown →