CCDC22

Across TCGA cell cohorts, CCDC22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,459 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CCDC22-associated GO terms across cancer lineages are Positive regulation of type 2 mitophagy, Growth hormone secretion, and Regulation of protein sumoylation. Each is linked with CCDC22 in more than 14 cancer types. Because this analysis shows association rather than direction, both CCDC22-to-partner and partner-to-CCDC22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of type 2 mitophagy grouped by CCDC22-low versus CCDC22-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC22→partner) and Y-score (partner→CCDC22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of type 2 mitophagy →	+0.132	+0.984	<.001	.001	3	15
LUNG_NSCLC_LUSC	Growth hormone secretion →	+0.122	+1.043	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of protein sumoylation →	+0.118	+0.720	<.001	<.001	3	14
BONE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.143	+0.595	<.001	<.001	3	13
STOMACH	Type 2 mitophagy →	+0.192	+0.787	<.001	<.001	3	12
URINARY_TRACT	Tubulin deacetylation →	+0.097	+0.695	.003	.002	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,459 associations by consensus.

Positive regulation of type 2 mitophagy by CCDC22 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →