CCDC198

Across TCGA patient cohorts, CCDC198 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC198-associated genes across cancer lineages are PI3K-p85, EGFR_pY1068, and Tuberin. Each is linked with CCDC198 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC198-to-partner and partner-to-CCDC198 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PI3K-p85 grouped by CCDC198-low versus CCDC198-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC198→partner) and Y-score (partner→CCDC198) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PI3K-p85 →	+0.262	+3.000	.030	.037	3	1
UCEC	EGFR_pY1068 →	-0.288	-3.000	.047	.037	2	1
UCEC	Tuberin →	+0.430	+3.009	.005	.019	2	1
UCEC	A-Raf_pS299 →	-0.140	-3.000	.043	.037	1	1
UCEC	Ku80 →	+0.282	+3.013	.038	.019	1	1
UCEC	TIGAR →	+0.196	+3.026	.026	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

PI3K-p85 by CCDC198 expression — UCEC

Explore this box plot interactively →