Across TCGA patient cohorts, CCDC189 mutation is significantly associated with the RNA expression of many other genes, with 1,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC189-associated genes across cancer lineages are TRAJ42, TRAJ25, and YPEL5P1. Each is linked with CCDC189 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC189-to-partner and partner-to-CCDC189 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC189→partner) and Y-score (partner→CCDC189) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TRAJ42 →	+1.280	+4.415	<.001	.006	3	2
COAD	TRAJ25 →	+0.554	+5.003	<.001	.004	3	2
COAD	YPEL5P1 →	+0.208	+4.893	<.001	.005	3	2
COAD	MIR4774 →	+0.731	+4.516	.005	.009	3	2
LUAD	MED15P1 →	+0.047	+4.315	<.001	.007	3	2
BRCA	MIR548H4 →	+0.257	+8.055	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,777 associations by consensus.

Exploration

CCDC189 survival (RNA) · tumor vs normal (RNA) · all CCDC189 data types