Across TCGA patient cohorts, CCDC189 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC189-associated genes across cancer lineages are GAPDH, JNK_pT183_Y185, and Lck. Each is linked with CCDC189 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC189-to-partner and partner-to-CCDC189 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC189→partner) and Y-score (partner→CCDC189) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.606	+3.169	.019	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.261	-2.446	.001	.020	3	1
UCEC	Lck →	+0.236	+2.459	.015	.020	3	1
UCEC	mTOR_pS2448 →	-0.165	-3.150	.021	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.249	+2.472	.012	.011	3	1
UCEC	Myosin-IIa →	+0.304	+2.466	<.001	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

CCDC189 survival (RNA) · tumor vs normal (RNA) · all CCDC189 data types