Across TCGA patient cohorts, CCDC180 mutation is significantly associated with the RNA expression of many other genes, with 3,089 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC180-associated genes across cancer lineages are GPRIN1, SKA1, and PKN3. Each is linked with CCDC180 in more than 3 cancer types. Because this analysis shows association rather than direction, both CCDC180-to-partner and partner-to-CCDC180 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC180→partner) and Y-score (partner→CCDC180) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GPRIN1 →	+0.732	+2.847	<.001	.001	3	4
COAD	SKA1 →	+0.803	+3.727	<.001	<.001	3	3
UCEC	PKN3 →	+0.511	+1.536	<.001	.001	3	3
UCEC	LZIC →	+0.323	+1.198	.008	.008	3	3
UCEC	NUDT2 →	+0.422	+1.732	<.001	<.001	3	3
UCEC	CHAF1A →	+0.447	+2.136	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,089 associations by consensus.

Exploration

CCDC180 survival (RNA) · tumor vs normal (RNA) · all CCDC180 data types