CCDC18

Across TCGA pan-cancer cohorts, CCDC18 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CCDC18 data layer compared with 27 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CCDC18 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated CCDC18 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, PDAC, and HNSC are the cancer types where CCDC18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	III,IV	1.000	0.462	.027	12	view →
PDAC	DFS	Median	II,III,IV	0.861	0.331	.005	7	view →
HNSC	DFS	Tertile	All	0.814	0.499	.010	7	view →
GBM	DFS	Median	All	0.481	0.204	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CCDC18–UCEC (OS)

Open the UCEC breakdown →