CCDC18

Across TCGA patient cohorts, CCDC18 mutation is significantly associated with the RNA expression of many other genes, with 2,488 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC18-associated genes across cancer lineages are MRPL40, RN7SL478P, and RNA5SP34. Each is linked with CCDC18 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC18-to-partner and partner-to-CCDC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL40 grouped by CCDC18-low versus CCDC18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC18→partner) and Y-score (partner→CCDC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL40 →	+0.342	+1.579	<.001	.007	3	3
UCEC	RN7SL478P →	+0.135	+1.461	.003	.002	3	2
CESC	RNA5SP34 →	+0.272	+6.589	<.001	<.001	3	2
CESC	PMM2P1 →	+0.057	+4.757	<.001	.004	3	2
UCEC	TXN2 →	+0.322	+2.599	<.001	<.001	3	2
UCEC	PHF5A →	+0.507	+2.502	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,488 associations by consensus.

MRPL40 by CCDC18 expression — UCEC

Explore this box plot interactively →