CCDC18

Across TCGA patient cohorts, CCDC18 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC18-associated genes across cancer lineages are EGFR_pY1068, ATM, and Cyclin-E2. Each is linked with CCDC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC18-to-partner and partner-to-CCDC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CCDC18-low versus CCDC18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC18→partner) and Y-score (partner→CCDC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.173	-1.643	.026	.003	3	2
UCEC	ATM →	-0.477	-1.893	<.001	<.001	3	2
UCEC	Cyclin-E2 →	+0.138	+1.290	.008	.034	3	2
UCEC	14-3-3_beta →	-0.074	-2.295	.017	.005	3	1
UCEC	ERK2 →	+0.151	+2.222	.011	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.181	-2.459	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by CCDC18 expression — UCEC

Explore this box plot interactively →