CCDC18

Across TCGA cell cohorts, CCDC18 mutation is significantly associated with the RNA expression of many other genes, with 499 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC18-associated genes across cancer lineages are PPDPFL, OR52E2, and BARHL2. Each is linked with CCDC18 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC18-to-partner and partner-to-CCDC18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPDPFL grouped by CCDC18-low versus CCDC18-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC18→partner) and Y-score (partner→CCDC18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PPDPFL →	+0.033	+4.906	<.001	.006	3	2
BLOOD_Leukemia	OR52E2 →	+0.016	+4.969	<.001	.003	3	2
BREAST	BARHL2 →	+0.095	+3.700	<.001	.002	3	2
OESOPHAGUS	SCYGR10 →	+0.203	+4.906	<.001	.006	3	1
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
BLOOD_Leukemia	MC3R →	+0.017	+5.569	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 499 associations by consensus.

PPDPFL by CCDC18 expression — OESOPHAGUS

Explore this box plot interactively →