CCDC178

Across TCGA pan-cancer cohorts, CCDC178 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated CCDC178 data layer compared with 21 for mass-spec protein.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher CCDC178 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC178 expression acts as an unfavorable survival marker, although some lineages such as SKCM and SCLC show a favorable association.

DLBC, CESC, and LUAD are the cancer types where CCDC178 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
CESC	DFS	Median	II,III,IV	0.140	0.785	<.001	18	view →
LUAD	OS	Median	III,IV	0.388	0.671	<.001	12	view →
SARC	OS	Median	All	0.205	0.826	<.001	9	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
COAD	OS	Median	II,III,IV	0.464	0.853	.014	3	view →
LIHC	DFS	Median	All	0.264	0.560	.002	3	view →
SKCM	DFS	Median	II,III,IV	0.810	0.537	.019	2	view →
SCLC	DFS	Median	All	1.000	0.598	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

CCDC178–DLBC (DFS)

Open the DLBC breakdown →