CCDC175

Across TCGA cell cohorts, CCDC175 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CCDC175-associated genes across cancer lineages are NXF5, KLHL1, and OR1L6. Each is linked with CCDC175 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC175-to-partner and partner-to-CCDC175 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NXF5 grouped by CCDC175-low versus CCDC175-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC175→partner) and Y-score (partner→CCDC175) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	NXF5 →	+0.036	+3.977	<.001	.006	3	1
LIVER	KLHL1 →	+0.014	+3.977	<.001	.006	3	1
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
LARGE_INTESTINE	SLC6A19 →	+0.865	+3.497	.009	.004	3	1
LUNG_SCLC	LUZP4 →	+0.994	+4.044	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

NXF5 by CCDC175 expression — LIVER

Explore this box plot interactively →