CCDC174

Across TCGA pan-cancer cohorts, CCDC174 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated CCDC174 data layer compared with 21 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher CCDC174 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC174 expression acts as an unfavorable survival marker.

THYM, LIHC, and SKCM are the cancer types where CCDC174 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LIHC	DFS	Median	All	0.070	0.555	<.001	12	view →
SKCM	OS	Median	IV	0.415	0.861	.014	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

CCDC174–THYM (OS)

Open the THYM breakdown →