CCDC174

Across TCGA pan-cancer cohorts, CCDC174 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CCDC174 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CCDC174 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated CCDC174 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

HNSC, PDAC, and LSCC are the cancer types where CCDC174 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.215	0.810	.010	21	view →
PDAC	OS	Median	All	0.945	0.779	.010	14	view →
LSCC	OS	Quartile	All	0.971	0.814	.014	13	view →
CCRCC	DFS	Quartile	II,III,IV	0.766	1.000	.029	7	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CCDC174–HNSC (DFS)

Open the HNSC breakdown →