CCDC174

Across TCGA patient cohorts, CCDC174 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC174-associated genes across cancer lineages are Caspase-7-cleavedD198, 14-3-3_beta, and EGFR_pY1068. Each is linked with CCDC174 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC174-to-partner and partner-to-CCDC174 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCDC174-low versus CCDC174-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC174→partner) and Y-score (partner→CCDC174) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.834	+2.479	.001	.010	3	2
UCEC	14-3-3_beta →	-0.100	-3.143	.022	.018	3	1
UCEC	EGFR_pY1068 →	-0.304	-3.321	.005	.009	3	1
UCEC	ER-alpha_pS118 →	-0.317	-3.000	.043	.036	3	1
UCEC	ERK2 →	+0.232	+2.115	.005	.019	3	1
UCEC	ETS-1 →	+0.318	+2.115	.022	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Caspase-7-cleavedD198 by CCDC174 expression — UCEC

Explore this box plot interactively →