CCDC172

Across TCGA patient cohorts, CCDC172 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC172-associated genes across cancer lineages are P-Cadherin, PCNA, and STAT3_pY705. Each is linked with CCDC172 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC172-to-partner and partner-to-CCDC172 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, P-Cadherin grouped by CCDC172-low versus CCDC172-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC172→partner) and Y-score (partner→CCDC172) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	P-Cadherin →	+0.249	+2.824	.041	.036	3	1
UCEC	PCNA →	+0.251	+3.169	.034	.020	3	1
UCEC	STAT3_pY705 →	-0.425	-3.169	.003	.020	3	1
UCEC	ATM →	-0.878	-3.169	<.001	.020	3	1
LUSC	ETS-1 →	+0.155	+3.009	.041	.019	1	1
LUSC	FOXO3a_pS318_S321 →	+0.134	+3.027	.042	.018	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

P-Cadherin by CCDC172 expression — LUAD

Explore this box plot interactively →