CCDC169

Across TCGA patient cohorts, CCDC169 mutation is significantly associated with the RNA expression of many other genes, with 178 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC169-associated genes across cancer lineages are MIR6507, MIR6806, and MIR5591. Each is linked with CCDC169 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC169-to-partner and partner-to-CCDC169 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6507 grouped by CCDC169-low versus CCDC169-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC169→partner) and Y-score (partner→CCDC169) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR6507 →	+0.359	+8.055	<.001	.007	3	1
LIHC	MIR6806 →	+0.579	+4.119	<.001	.004	3	1
LIHC	MIR5591 →	+0.579	+4.374	.003	.002	3	1
BRCA	RPPH1-2P →	+0.103	+7.731	<.001	.009	3	1
BRCA	RNA5SP70 →	+0.330	+7.731	<.001	.009	3	1
BRCA	TGIF2LY →	+0.039	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 178 associations by consensus.

MIR6507 by CCDC169 expression — BRCA

Explore this box plot interactively →