CCDC166

Across TCGA patient cohorts, CCDC166 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,527 significant associations in total. STAD shows the largest number of these associations.

The most reproducible CCDC166-associated GO terms across cancer lineages are Regulation of spindle organization, Spindle organization, and tRNA 5'-leader removal. Each is linked with CCDC166 in more than 13 cancer types. Because this analysis shows association rather than direction, both CCDC166-to-partner and partner-to-CCDC166 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of spindle organization grouped by CCDC166-low versus CCDC166-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC166→partner) and Y-score (partner→CCDC166) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Regulation of spindle organization →	+0.060	+0.159	.001	.001	2	14
STAD	Spindle organization →	+0.045	+0.155	<.001	<.001	3	11
STAD	tRNA 5'-leader removal →	+0.035	+0.151	<.001	<.001	3	11
STAD	Mitotic intra-S DNA damage checkpoint signaling →	+0.034	+0.136	<.001	<.001	3	11
STAD	Ribosomal large subunit biogenesis →	+0.048	+0.174	<.001	<.001	3	11
STAD	Mitotic spindle assembly →	+0.046	+0.165	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,527 associations by consensus.

Regulation of spindle organization by CCDC166 expression — ESCA

Explore this box plot interactively →