CCDC166

Across TCGA patient cohorts, CCDC166 mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC166-associated genes across cancer lineages are RNA5SP261, USP17L3, and ATP6V1G3. Each is linked with CCDC166 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC166-to-partner and partner-to-CCDC166 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP261 grouped by CCDC166-low versus CCDC166-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC166→partner) and Y-score (partner→CCDC166) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNA5SP261 →	+0.291	+8.055	<.001	.007	3	1
BRCA	USP17L3 →	+0.024	+8.055	<.001	.007	3	1
UCEC	ATP6V1G3 →	+0.999	+2.695	<.001	.004	3	1
UCEC	ALX3 →	+0.601	+3.968	.005	<.001	3	1
UCEC	SSTR5 →	+0.564	+2.871	.009	.008	3	1
UCEC	ZIC5 →	+1.648	+3.600	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

RNA5SP261 by CCDC166 expression — BRCA

Explore this box plot interactively →