CCDC166

Across TCGA cell cohorts, CCDC166 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC166-associated genes across cancer lineages are KRTAP6-1, PPEF2, and COX6A2. Each is linked with CCDC166 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC166-to-partner and partner-to-CCDC166 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KRTAP6-1 grouped by CCDC166-low versus CCDC166-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC166→partner) and Y-score (partner→CCDC166) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	KRTAP6-1 →	+0.070	+5.643	<.001	.002	3	1
LARGE_INTESTINE	PPEF2 →	+0.035	+3.736	<.001	.007	3	1
LARGE_INTESTINE	COX6A2 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	FCN2 →	+0.028	+4.000	<.001	<.001	3	1
LARGE_INTESTINE	C1QTNF7 →	+0.117	+4.523	<.001	.001	3	1
LARGE_INTESTINE	MYT1L →	+0.155	+3.333	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

KRTAP6-1 by CCDC166 expression — LUNG_SCLC

Explore this box plot interactively →