CCDC166

Across TCGA cell cohorts, CCDC166 mutation is significantly associated with the mutation status of many other genes, with 838 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC166-associated genes across cancer lineages are ZNF594, ADAMTS2, and SUPT5H. Each is linked with CCDC166 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC166-to-partner and partner-to-CCDC166 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF594 grouped by CCDC166-low versus CCDC166-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC166→partner) and Y-score (partner→CCDC166) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZNF594 →	+5.502	+5.502	.003	.003	1	2
LARGE_INTESTINE	ADAMTS2 →	+2.215	+3.247	.003	.003	1	2
LARGE_INTESTINE	SUPT5H →	+1.951	+3.015	.006	.006	1	2
LARGE_INTESTINE	STYXL2 →	+2.407	+2.886	.008	.008	1	2
LARGE_INTESTINE	ELFN1 →	+2.536	+3.504	.001	.001	1	2
LARGE_INTESTINE	ABCA7 →	+2.367	+3.372	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 838 associations by consensus.

ZNF594 by CCDC166 expression — LUNG_SCLC

Explore this box plot interactively →