CCDC158

Across TCGA cell cohorts, CCDC158 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,057 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CCDC158-associated GO terms across cancer lineages are Negative regulation of myoblast fusion, Regulation of amino acid metabolic process, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with CCDC158 in more than 6 cancer types. Because this analysis shows association rather than direction, both CCDC158-to-partner and partner-to-CCDC158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of myoblast fusion grouped by CCDC158-low versus CCDC158-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC158→partner) and Y-score (partner→CCDC158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Negative regulation of myoblast fusion →	+0.078	+0.257	.004	.009	3	7
BLOOD_Lymphoma	Regulation of amino acid metabolic process →	+0.105	+0.006	.001	.009	3	6
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.077	+0.261	.005	.008	3	6
BREAST	Negative regulation of calcium ion export across plasma membrane →	+0.051	+0.243	.003	.005	3	6
UPPER_AERODIGESTIVE_TRACT	ERAD pathway →	+0.053	+0.062	.002	.005	3	5
LUNG_NSCLC_LUAD	Regulation of syncytium formation by plasma membrane fusion →	+0.062	+0.127	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,057 associations by consensus.

Negative regulation of myoblast fusion by CCDC158 expression — BREAST

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