CCDC158

Across TCGA cell cohorts, CCDC158 mutation is significantly associated with the RNA expression of many other genes, with 61 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible CCDC158-associated genes across cancer lineages are TBATA, DEFB125, and OR10J1. Each is linked with CCDC158 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC158-to-partner and partner-to-CCDC158 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBATA grouped by CCDC158-low versus CCDC158-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC158→partner) and Y-score (partner→CCDC158) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	TBATA →	+0.013	+5.369	<.001	.004	3	2
LUNG_SCLC	DEFB125 →	+0.086	+5.643	<.001	.002	3	2
BLOOD_Leukemia	OR10J1 →	+0.018	+4.984	<.001	.002	3	2
SOFT_TISSUE	C20orf85 →	+0.115	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR1L4 →	+0.072	+5.369	<.001	.004	3	1
SOFT_TISSUE	OR4D6 →	+0.046	+5.977	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 61 associations by consensus.

TBATA by CCDC158 expression — SOFT_TISSUE

Explore this box plot interactively →