Across TCGA patient cohorts, CCDC154 mutation is significantly associated with the RNA expression of many other genes, with 1,491 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC154-associated genes across cancer lineages are TUBB1P1, LYZL2, and SERPINB7. Each is linked with CCDC154 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC154-to-partner and partner-to-CCDC154 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC154→partner) and Y-score (partner→CCDC154) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TUBB1P1 →	+0.008	+3.292	.002	.003	3	2
SCLC	LYZL2 →	+0.206	+4.847	.001	.009	3	1
SCLC	SERPINB7 →	+0.576	+5.189	<.001	.006	3	1
SCLC	TSPY8 →	+1.784	+5.189	<.001	.006	3	1
SCLC	OR2L8 →	+0.339	+5.189	<.001	.006	3	1
SCLC	CFHR2 →	+0.146	+4.847	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,491 associations by consensus.

Exploration

CCDC154 survival (RNA) · tumor vs normal (RNA) · all CCDC154 data types