Across TCGA patient cohorts, CCDC154 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC154-associated genes across cancer lineages are FASN, ASNS, and 14-3-3_beta. Each is linked with CCDC154 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC154-to-partner and partner-to-CCDC154 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC154→partner) and Y-score (partner→CCDC154) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.526	+3.000	.001	.001	3	2
UCEC	ASNS →	+0.460	+2.321	.002	.006	3	2
UCEC	14-3-3_beta →	-0.108	-2.973	.009	.035	3	1
UCEC	EGFR_pY1068 →	-0.289	-2.459	.005	.018	3	1
UCEC	eIF4E →	+0.229	+2.335	.008	.018	3	1
UCEC	eIF4G →	+0.263	+1.807	.040	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

CCDC154 survival (RNA) · tumor vs normal (RNA) · all CCDC154 data types