CCDC153

Across TCGA pan-cancer cohorts, CCDC153 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated CCDC153 data layer compared with 2 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CCDC153 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC153 expression acts as an unfavorable survival marker, although some lineages such as MESO and LUAD show a favorable association.

UVM, LGG, and MESO are the cancer types where CCDC153 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Quartile	All	0.605	1.000	.003	58	view →
LGG	OS	Median	All	0.694	0.911	<.001	53	view →
MESO	OS	Median	All	0.479	0.293	.005	52	view →
LUAD	DFS	Median	All	0.837	0.744	.001	48	view →
SKCM	OS	Tertile	IV	0.867	0.234	.001	40	view →
BLCA	OS	Median	II,III,IV	0.690	0.535	.001	28	view →
COAD	DFS	Median	All	0.587	0.773	<.001	18	view →
PRAD	DFS	Median	All	0.839	0.928	<.001	18	view →
HNSC	OS	Median	II,III,IV	0.732	0.613	.008	16	view →
CHOL	DFS	Quartile	All	1.000	0.116	.014	15	view →
THYM	DFS	Median	II,III,IV	0.934	0.766	.012	11	view →
KIRC	DFS	Quartile	II,III,IV	0.668	0.826	.028	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

CCDC153–UVM (OS)

Open the UVM breakdown →