CCDC15

Across TCGA patient cohorts, CCDC15 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC15-associated genes across cancer lineages are Notch1, ATM, and eIF4E. Each is linked with CCDC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC15-to-partner and partner-to-CCDC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by CCDC15-low versus CCDC15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC15→partner) and Y-score (partner→CCDC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.222	+2.247	<.001	.001	3	2
UCEC	ATM →	-0.558	-2.321	<.001	.005	3	2
UCEC	eIF4E →	+0.204	+2.247	.008	.001	2	2
UCEC	eIF4G →	+0.264	+2.459	.020	.018	3	1
UCEC	FoxM1 →	+0.227	+1.502	.017	.030	3	1
UCEC	MIG-6 →	+0.087	+1.861	.016	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

Notch1 by CCDC15 expression — UCEC

Explore this box plot interactively →