CCDC15

Across TCGA cell cohorts, CCDC15 mutation is significantly associated with the RNA expression of many other genes, with 1,354 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC15-associated genes across cancer lineages are SPATA31D1, CRYBB1, and IL36A. Each is linked with CCDC15 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC15-to-partner and partner-to-CCDC15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA31D1 grouped by CCDC15-low versus CCDC15-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC15→partner) and Y-score (partner→CCDC15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SPATA31D1 →	+0.006	+5.228	<.001	.005	3	2
BREAST	CRYBB1 →	+0.373	+5.781	<.001	.001	3	1
BREAST	IL36A →	+0.057	+5.169	<.001	.005	3	1
BREAST	MTRNR2L10 →	+0.019	+5.169	<.001	.005	3	1
LUNG_SCLC	OR51Q1 →	+0.100	+3.762	.003	.003	3	1
LUNG_SCLC	SIGLEC7 →	+0.484	+3.869	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,354 associations by consensus.

SPATA31D1 by CCDC15 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →