CCDC149

Across TCGA pan-cancer cohorts, CCDC149 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated CCDC149 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher CCDC149 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC149 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

CCRCC, LUAD, and UCEC are the cancer types where CCDC149 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.925	0.383	<.001	14	view →
LUAD	DFS	Tertile	III,IV	0.529	0.833	.041	3	view →
UCEC	OS	Tertile	All	1.000	0.873	.046	2	view →
LSCC	OS	Median	III,IV	0.938	0.777	.038	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

CCDC149–CCRCC (DFS)

Open the CCRCC breakdown →