CCDC149

Across TCGA pan-cancer cohorts, CCDC149 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of CCDC149’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where CCDC149 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types CCDC149 is over-expressed in tumor, although a few such as PDAC and LSCC show the opposite, repressed pattern.

PDAC, LSCC, and HNSC are the cancer types where CCDC149 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CCDC149 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	II,III,IV	−1.350	<.001	9	view →
LSCC	Male	II,III,IV	−0.496	<.001	9	view →
HNSC	All	II,III,IV	−0.340	.026	3	view →
LUAD	Male	All	−0.166	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

CCDC149–PDAC

Open the PDAC breakdown →