CCDC149

Across TCGA cell cohorts, CCDC149 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CCDC149-associated genes across cancer lineages are IZUMO3, BAG2, and NASP. Each is linked with CCDC149 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC149-to-partner and partner-to-CCDC149 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IZUMO3 grouped by CCDC149-low versus CCDC149-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC149→partner) and Y-score (partner→CCDC149) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	IZUMO3 →	+0.036	+4.643	<.001	.008	3	1
LARGE_INTESTINE	BAG2 →	+1.126	+3.087	.002	.006	3	1
LARGE_INTESTINE	NASP →	+0.660	+3.064	<.001	.009	3	1
LARGE_INTESTINE	ADAM21 →	+0.718	+3.064	<.001	.009	3	1
LARGE_INTESTINE	C8A →	+0.018	+2.777	<.001	.004	3	1
LARGE_INTESTINE	C9orf153 →	+0.157	+3.497	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

IZUMO3 by CCDC149 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →