CCDC148

Across TCGA patient cohorts, CCDC148 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC148-associated genes across cancer lineages are VHL, 4E-BP1, and eIF4G. Each is linked with CCDC148 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC148-to-partner and partner-to-CCDC148 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CCDC148-low versus CCDC148-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC148→partner) and Y-score (partner→CCDC148) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.745	-1.906	.003	.015	3	2
UCEC	4E-BP1 →	+0.277	+2.145	.006	.009	3	2
UCEC	eIF4G →	+0.263	+2.999	.024	.035	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.449	+1.710	.018	.025	3	1
UCEC	JNK2 →	+0.205	+2.196	.006	.032	3	1
UCEC	Ku80 →	+0.205	+1.778	.020	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

VHL by CCDC148 expression — UCEC

Explore this box plot interactively →