CCDC146

Across TCGA patient cohorts, CCDC146 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,652 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible CCDC146-associated proteins across cancer lineages are TOP1_S394, SLC3A2, and LRRC59. Each is linked with CCDC146 in more than 4 cancer types. Because this analysis shows association rather than direction, both CCDC146-to-partner and partner-to-CCDC146 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CCDC146 versus TOP1_S394 in LUAD, with a Pearson correlation of -0.34.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC146→partner) and Y-score (partner→CCDC146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TOP1_S394 →	-0.678	-0.477	<.001	.003	3	4
BRCA	SLC3A2 →	-0.398	-0.532	<.001	<.001	3	4
OV	LRRC59 →	-0.486	-1.485	<.001	.003	3	4
OV	LTBP4 →	+1.038	+2.256	<.001	<.001	3	4
BRCA	BBS2 →	+0.364	+0.496	<.001	<.001	3	4
UCEC	BBS4 →	+0.490	+1.057	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,652 associations by consensus.

CCDC146 vs TOP1_S394 — LUAD

Explore this scatter interactively →