CCDC146

Across TCGA patient cohorts, CCDC146 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC146-associated genes across cancer lineages are eIF4E, STAT3_pY705, and FASN. Each is linked with CCDC146 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC146-to-partner and partner-to-CCDC146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CCDC146-low versus CCDC146-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC146→partner) and Y-score (partner→CCDC146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	eIF4E →	+0.243	+3.000	.002	.034	3	3
UCEC	STAT3_pY705 →	-0.383	-2.392	<.001	<.001	3	3
SKCM	FASN →	+0.690	+2.000	.001	.031	3	3
UCEC	GAPDH →	+0.335	+2.584	.036	.010	3	2
UCEC	mTOR_pS2448 →	-0.104	-1.752	.019	.011	3	2
UCEC	PCNA →	+0.228	+2.050	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

eIF4E by CCDC146 expression — SKCM

Explore this box plot interactively →