CCDC146

Across TCGA cell cohorts, CCDC146 mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible CCDC146-associated genes across cancer lineages are GFRA4, SIGLEC5, and ASB10. Each is linked with CCDC146 in more than 1 cancer types. Because this analysis shows association rather than direction, both CCDC146-to-partner and partner-to-CCDC146 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by CCDC146-low versus CCDC146-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC146→partner) and Y-score (partner→CCDC146) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	GFRA4 →	+0.022	+5.169	<.001	.005	3	2
PANCREAS	SIGLEC5 →	+0.018	+3.491	<.001	.008	3	1
PANCREAS	ASB10 →	+0.010	+4.029	<.001	.007	3	1
PANCREAS	CYLC1 →	+0.004	+4.029	<.001	.007	3	1
LUNG_NSCLC_LUSC	ELSPBP1 →	+0.204	+4.108	.005	.005	3	1
KIDNEY	SLC6A18 →	+0.036	+5.000	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

GFRA4 by CCDC146 expression — BREAST

Explore this box plot interactively →