CCDC144B

Across TCGA pan-cancer cohorts, CCDC144B RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CCDC144B data layer compared with 6 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher CCDC144B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CCDC144B expression acts as an unfavorable survival marker, although some lineages such as UCS and ESCA show a favorable association.

UVM, UCEC, and KICH are the cancer types where CCDC144B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	III,IV	0.321	0.912	<.001	72	view →
UCEC	OS	Median	All	0.895	0.954	.002	64	view →
KICH	DFS	Quartile	II,III,IV	0.531	1.000	.002	44	view →
COAD	DFS	Median	IV	0.323	0.595	.001	41	view →
UCS	DFS	Tertile	II,III,IV	0.454	0.095	.010	36	view →
LUSC	OS	Tertile	III,IV	0.266	0.524	.008	34	view →
CESC	DFS	Tertile	All	0.418	0.670	.009	28	view →
LGG	OS	Quartile	All	0.865	0.962	<.001	28	view →
BLCA	DFS	Quartile	All	0.430	0.610	.015	20	view →
KIRP	OS	Median	All	0.897	0.960	.006	15	view →
PCPG	OS	Quartile	All	0.729	1.000	.017	15	view →
ESCA	OS	Median	III,IV	0.670	0.440	.012	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CCDC144B–UVM (OS)

Open the UVM breakdown →