CCDC14

Across TCGA pan-cancer cohorts, CCDC14 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated CCDC14 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher CCDC14 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated CCDC14 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where CCDC14 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	0.990	0.558	.008	22	view →
LUAD	OS	Tertile	II,III,IV	1.000	0.478	.014	11	view →
CCRCC	DFS	Median	All	0.128	1.000	.038	11	view →
HNSC	DFS	Quartile	III,IV	0.316	0.909	.013	8	view →
UCEC	DFS	Tertile	III,IV	0.800	0.184	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

CCDC14–LSCC (DFS)

Open the LSCC breakdown →