CCDC14

Across TCGA patient cohorts, CCDC14 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC14-associated genes across cancer lineages are 4E-BP1, eEF2, and eIF4E. Each is linked with CCDC14 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC14-to-partner and partner-to-CCDC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by CCDC14-low versus CCDC14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC14→partner) and Y-score (partner→CCDC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.291	+2.532	<.001	<.001	3	3
UCEC	eEF2 →	+0.321	+2.115	.004	.016	3	2
UCEC	eIF4E →	+0.136	+2.713	.043	.003	3	2
UCEC	Ku80 →	+0.180	+1.536	.017	.005	3	2
UCEC	Annexin-1 →	+0.422	+2.107	.012	.002	3	2
UCEC	STAT3_pY705 →	-0.403	-2.321	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

4E-BP1 by CCDC14 expression — UCEC

Explore this box plot interactively →