CCDC14

Across TCGA cell cohorts, CCDC14 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,286 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CCDC14-associated GO terms across cancer lineages are DNA damage tolerance, Double-strand break repair, and DNA biosynthetic process. Each is linked with CCDC14 in more than 17 cancer types. Because this analysis shows association rather than direction, both CCDC14-to-partner and partner-to-CCDC14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA damage tolerance grouped by CCDC14-low versus CCDC14-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC14→partner) and Y-score (partner→CCDC14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	DNA damage tolerance →	+0.102	+1.635	<.001	<.001	3	18
SOFT_TISSUE	Double-strand break repair →	+0.091	+1.327	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	DNA biosynthetic process →	+0.087	+1.580	<.001	<.001	3	18
UPPER_AERODIGESTIVE_TRACT	Microtubule organizing center organization →	+0.090	+1.517	<.001	<.001	3	17
LARGE_INTESTINE	Microtubule polymerization or depolymerization →	+0.106	+1.134	<.001	<.001	3	17
BONE	Microtubule polymerization →	+0.117	+0.905	<.001	.004	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,286 associations by consensus.

DNA damage tolerance by CCDC14 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →