CCDC138

Across TCGA patient cohorts, CCDC138 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CCDC138-associated genes across cancer lineages are Caspase-7-cleavedD198, p62 Lck ligand, and PDCD4. Each is linked with CCDC138 in more than 2 cancer types. Because this analysis shows association rather than direction, both CCDC138-to-partner and partner-to-CCDC138 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by CCDC138-low versus CCDC138-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC138→partner) and Y-score (partner→CCDC138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.548	+2.604	.013	.005	3	3
UCEC	p62 Lck ligand →	+0.366	+2.817	.002	.001	3	2
UCEC	PDCD4 →	-0.421	-1.415	.017	.046	3	2
UCEC	Bax →	+0.217	+2.321	.015	.033	3	2
UCEC	EGFR_pY1068 →	-0.278	-2.700	.003	.005	3	1
UCEC	eIF4E →	+0.187	+3.013	.018	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Caspase-7-cleavedD198 by CCDC138 expression — UCEC

Explore this box plot interactively →