CCDC138

Across TCGA cell cohorts, CCDC138 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,218 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible CCDC138-associated GO terms across cancer lineages are DNA replication checkpoint signaling, Sister chromatid segregation, and Mitotic spindle assembly. Each is linked with CCDC138 in more than 18 cancer types. Because this analysis shows association rather than direction, both CCDC138-to-partner and partner-to-CCDC138 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication checkpoint signaling grouped by CCDC138-low versus CCDC138-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CCDC138→partner) and Y-score (partner→CCDC138) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA replication checkpoint signaling →	+0.185	+1.125	.001	.001	3	19
KIDNEY	Sister chromatid segregation →	+0.096	+1.169	<.001	<.001	3	19
BONE	Mitotic spindle assembly →	+0.115	+1.370	.006	.001	3	19
BLOOD_Myeloma	Nuclear chromosome segregation →	+0.102	+1.040	<.001	<.001	3	19
SKIN	Mitotic spindle organization →	+0.091	+0.602	<.001	<.001	3	19
BONE	Mitotic DNA replication checkpoint signaling →	+0.231	+1.245	<.001	.003	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,218 associations by consensus.

DNA replication checkpoint signaling by CCDC138 expression — BONE

Explore this box plot interactively →